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Practical synthesis of ynolate anions: naphthalene-catalyzed reductive lithiation of α,α-dibromo esters

✍ Scribed by Mitsuru Shindo; Ryoko Koretsune; Wakako Yokota; Kotaro Itoh; Kozo Shishido

Book ID
104231846
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
64 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Reductive lithiation of a,a-dibromo esters using lithium naphthalenide afforded ester dianions leading to ynolate anions in good yields. Naphthalene-catalyzed reductive lithiation was also accomplished. This is a convenient, economical and practical method for the preparation of ynolate anions.

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