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Practical synthesis of trans-dihydroxybutyrolactols as chiral C4 building blocks and their application to the synthesis of polyhydroxylated alkaloids

โœ Scribed by Zeng, Jing; Zhang, Qian; Zhang, Hong-Kui; Chen, Anqi


Book ID
127321009
Publisher
The Royal Society of Chemistry
Year
2013
Tongue
English
Weight
314 KB
Volume
3
Category
Article
ISSN
2046-2069

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One-flask synthesis of meso-substituted
โœ Chang-Hee Lee; Jonathan S. Lindsey ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 985 KB

The reaction at room temperature of an aldehyde with excess pyrrole in the absence of solvent affords the meso-substituted dipyrromethane. The reaction is catalyzed with trifluoroacetic acid or with BF9,0(Et)2. The dipyrromethaue is purified by crystallixation or by flash chromatography on silica wi