Synthesis of an inhibitor of sphingosine
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Ahcene Boumendjel; Stephen P.F. Miller
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Article
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1994
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Elsevier Science
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French
β 318 KB
The 24nyl ~hy~~~l-~~ 1. was syatbe&i and testesI for i~ibi~ of ~~~-~ Iyase. The carboo akeletoa was wepared by acylacion of a methioaiae imine with N-metboxy-N-methyl palmitatnide. The vinyl group was generated by thermal sulbxide eliiination. Reduction of both carbonyl groups and &protection gave P