Practical synthesis of methyl (E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate, a key intermediate of Montelukast
β Scribed by Liang He; Yang Hui Guo; Ya Ping Wang; Xiang Jing Wang; Ji Zhang; Wen Sheng Xiang
- Book ID
- 113523401
- Publisher
- Chinese Electronic Periodical Services
- Year
- 2012
- Tongue
- English
- Weight
- 276 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1001-8417
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π SIMILAR VOLUMES
## Abstract The enantiomers of [3β^3^H]β2β[[4β[(7βchloroβ4βquinolinyl)amino]pentyl]ethylamino]ethanol,[3β^3^H]βhydroxychloroquine, (R)β8 and (S)β8, have been prepared in two steps from the known precursors 4,7βdichloroβ3βiodoquinoline, 4, and the enantiomers of 2β[(4βaminopentyl)ethylamino]ethanol,
Tema~epam-2-'~C, 7-Chloro-1,3-ihydro-3-hydroxy-1 -methyl-5-phenyl-2H-1,4-benzodiazepin-2-one--"C, was prepared in a f ive-step synthesis. Chl~roacetic-l-~~C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowed to react with 2-methylamino-5-chloro-benzophenone