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Practical synthesis of hex-5-ynoic acid from cyclohexanone

โœ Scribed by E. K. Starostin; M. A. Lapitskaya; A. V. Ignatenko; K. K. Pivnitsky; G. I. Nikishin


Book ID
105598143
Publisher
Springer
Year
1990
Tongue
English
Weight
294 KB
Volume
49
Category
Article
ISSN
1573-9171

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Racemic 4,5-disubstitued 5H-furan-2-ones have been selectively synthesized by addition of 1.2-1.6 equiv of aryl, alkenyl or 1-alkynyl halides and catalytic amounts of Pd(OAc)2 and a soft ligand such as tri-2-furylphosphine or triphenylarsine to the reaction mixtures obtained by treatment of 3-ynoic