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Practical Synthesis of an Enantiomerically Pure trans- 4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB 4 Inhibitor BIRZ-227 †

✍ Scribed by Yee, Nathan K.; Nummy, Laurence J.; Byrne, Denis P.; Smith, Lana L.; Roth, Gregory P.

Book ID
126212158
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
102 KB
Volume
63
Category
Article
ISSN
0022-3263

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ChemInform Abstract: Practical Synthesis
ChemInform Abstract: Practical Synthesis of an Enantiomerically Pure trans-4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB4 Inhibitor BIRZ-227.
✍ N. K. YEE; L. J. NUMMY; D. P. BYRNE; L. L. SMITH; G. P. ROTH 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views

Practical Synthesis of an Enantiomerically Pure trans-4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB 4 Inhibitor BIRZ-227. -The efficient synthesis of rac. (II) in a simple one-pot procedure was already described. A novel enzymatic resolution of its rac derivative