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Practical Synthesis of a Vanilloid Receptor-1 Antagonist

โœ Scribed by Thiel, Oliver R.; Bernard, Charles; King, Tony; Dilmeghani-Seran, Mina; Bostick, Tracy; Larsen, Robert D.; Faul, Margaret M.

Book ID
127057025
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
232 KB
Volume
73
Category
Article
ISSN
0022-3263

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Development of a Large Scale Asymmetric
Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102
โœ Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatram ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 104 KB

A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of it