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Practical Synthesis of 4-Chloro-2-(2-naphthyl)quinoline, a Precursor to Triple-Helix DNA Intercalators

โœ Scribed by Strekowski, Lucjan; Zegrocka, Oliwia; Windham, Christopher; Czarny, Agnieszka


Book ID
115448460
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
127 KB
Volume
1
Category
Article
ISSN
1083-6160

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ChemInform Abstract: Practical Synthesis
โœ L. STREKOWSKI; O. ZEGROCKA; C. WINDHAM; A. CZARNY ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB

Practical Synthesis of 4-Chloro-2-(2-naphthyl)quinoline, a Precursor to Triple-Helix DNA Intercalators. -Use of phosphorus pentachloride in a mixture with phosphorus oxychloride improves the efficiency of the last reaction step in the synthesis of title compound (V) from 75% to 86% yield. Nucleophil