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Practical Solid-Phase Parallel Synthesis of Δ 5 -2-Oxopiperazines via N -Acyliminium Ion Cyclization

✍ Scribed by Lee, Sung-Chan; Park, Seung Bum


Book ID
121316041
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
485 KB
Volume
9
Category
Article
ISSN
1520-4766

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✍ Jie-Fei Cheng; Mi Chen; Thomas Arrhenius; Alex Nadzan 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 95 KB

An extremely efficient synthesis of D 5 -2-oxopiperazines in solution phase and on solid support has been established via a Ugi four-component condensation reaction (U-4CC) followed by N-acyliminium ion cyclization between the aldehyde (acetal) functionality and the newly formed amide bond. The desi