A convenient solution and solid-phase sy
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Jie-Fei Cheng; Mi Chen; Thomas Arrhenius; Alex Nadzan
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Article
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2002
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Elsevier Science
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French
⚖ 95 KB
An extremely efficient synthesis of D 5 -2-oxopiperazines in solution phase and on solid support has been established via a Ugi four-component condensation reaction (U-4CC) followed by N-acyliminium ion cyclization between the aldehyde (acetal) functionality and the newly formed amide bond. The desi