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Practical Route to a New Class of LTD4 Receptor Antagonists

✍ Scribed by Xiang, Yi Bin; Larsen, Robert D.; Corley, Edward G.; King, Anthony O.; Carroll, James D.; Davis, Paul; Verhoeven, Thomas R.; Reider, Paul J.; Labelle, Marc; Gauthier, Jacques Y.


Book ID
115477326
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
329 KB
Volume
61
Category
Article
ISSN
0022-3263

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Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K~ value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected