Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines

✍ Scribed by Andreas Link; Serge van Calenbergh; Piet Herdewijn

• Book ID: 104259540
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 111 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01057-0

✦ Synopsis

A new synthetic strategy for the simple and high yielding preparation of arrays of 2"-amido-2"-deoxyadenosine derivatives ready for biological testing without the need for chromatographic purification is described. Acids are coupled to the Kenner or Ellman safety catch linker, respectively, activated by cyanomethylation and subsequently transferred to the 2"-amino group of 2"-amino-2"-deoxyadenosine.