𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Practical kinetics I: Quantitation of barbiturate stability by TLC

✍ Scribed by H. V. Maulding; J. Polesuk; D. Rosenbaum

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
331 KB
Volume
64
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

The purpose of this work was the application of established techniques to the quantitation of stability investigations of liquid formulations as well as in solution kinetic studies. The process consists of streaking aliquots of reaction solution on TLC plates, development, elution, and analysis of the substances in the eluate. Several barbiturates were investigated regarding thejr decomposition at elevated temperatures. Reasonable correlation is noted between obtained rate constants and literature data. This technique represents a utilitarian approach to stability screening of compounds in solution, aqueous or otherwise, where chromatographic separation and analytical methodology for the pure compound are available.

Keyphrases 0 Barbiturates-stability, quantitation by TLC Stability-barbiturates, quantitation by TLC 0 TLC-monitoring and quantitating bar6iturate stability

📜 SIMILAR VOLUMES

Quantitative structure–stability relatio
Quantitative structure–stability relationships among inclusion complexes of cyclodextrins I: Barbituric acid derivatives
✍ Antal Lopata; Ferenc Darvas; Ágnes Stadler-Szóke; József Szejtli 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB

Quantitative structure-stability relationships (QSSRs) are formulated for the inclusion complexation of 17 barbituric acid derivatives with alpha- and beta-cyclodextrin. The variation in the complex stability constants K alpha and K beta is found to be partly accounted for by the molar refractivity

A Quantitative study of alkyl radical re
A Quantitative study of alkyl radical reactions by kinetic spectroscopy. Part I. Mutual combination of methyl radicals and combination of methyl radicals with nitric oxide
✍ N. Basco; D. G. L. James; R. D. Suart 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 English ⚖ 935 KB

## Abstract Combination reactions of the methyl radical have been studied by following the decay of the absorbance of the methyl radical during the course of the reaction by means of kinetic spectroscopy. The limiting values of the second‐order rate constants at high pressure were determined for tw