Practical implementation of single-voxel double-quantum editing on a whole-body NMR spectrometer: Localized monitoring of lactate in the human leg during and after exercise
✍ Scribed by Laurence Jouvensal; Pierre G. Carlier; Gilles Bloch
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 461 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
The classical double‐quantum editing sequence 90°~x~‐τ−180°~y~‐τ−90°~x~‐t~1~−90°~x~‐τ−180°~y~‐τ‐AQ (τ = 1/4J) was rendered volume selective, by making slice selective the first 90° pulse and the two 180° pulses. Using simple rules to ensure optimum radio frequency phase coherence, this single‐voxel editing sequence, reminiscent of a basic PRESS localization technique, was implemented on a whole‐body 3 T spectrometer, and in vitro editing of lactate methyl protons was demonstrated without any significant loss in intrinsic sensitivity. The effectiveness of the proposed approach in vivo was also illustrated through the localized monitoring of lactate in the human leg during and after exercise.