✦ LIBER ✦

Practical considerations in development of solid dosage forms that contain cyclodextrin

✍ Scribed by Lee A. Miller; Rebecca L. Carrier; Imran Ahmed

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 219 KB
Volume: 96
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20831

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✦ Synopsis

The following is a review of the literature that addresses the use of cyclodextrin in solid dosage forms. Care was taken to exclude physical and chemical characteristics of cyclodextrin, which have been discussed in the literature. A flow diagram is provided to outline the decision-making steps that are involved in the development process. Both preparation of physical mixtures and inclusion complexes are considered. Analytical techniques to determine the presence of inclusion complexes, the effect of other excipients on complex formation, the effect of size limitation of solid dosages forms, powder processing, and storage of solid dosage forms are discussed.

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