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Practical Asymmetric Synthesis of α-Branched 2-Piperazinylbenzylamines by 1,2-Additions of Organometallic Reagents to N - tert -Butanesulfinyl Imines

✍ Scribed by Jiang, Wanlong; Chen, ; Marinkovic, Dragan; Tran, Joe A.; Chen, Caroline W.; Arellano, L. Melissa; White, Nicole S.; Tucci, Fabio C.


Book ID
120034203
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
182 KB
Volume
70
Category
Article
ISSN
0022-3263

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Asymmetric synthesis of α,α-diaryl and α
✍ Anthony W Shaw; S.Jane deSolms 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 105 KB

Organometallic addition to tert-butanesufinyl ketimines derived from diaryl and aryl-heteroaryl ketones provided the corresponding a,a-diaryl and a-aryl-a-heteroaryl alkylamines in good yield with high diastereoselectivity. In many cases, imine facial selectivity is reversed on changing the organome