Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction

✍ Scribed by Zhao, Matthew M.; McNamara, James M.; Ho, Guo-Jie; Emerson, Khateeta M.; Song, Zhiguo J.; Tschaen, David M.; Brands, Karel M. J.; Dolling, Ulf-H; Grabowski, Edward J. J.; Reider, Paul J.; Cottrell, Ian F.; Ashwood, Michael S.; Bishop, Brian C.

• Book ID: 120054306
• Publisher: American Chemical Society
• Year: 2002
• Tongue: English
• Weight: 111 KB
• Volume: 67
• Category: Article
• ISSN: 0022-3263
• DOI: 10.1021/jo0203793