✦ LIBER ✦

Practical approach to steroid 5alpha-reductase type 2 deficiency

✍ Scribed by Chong Kun Cheon

Publisher: Springer
Year: 2010
Tongue: English
Weight: 325 KB
Volume: 170
Category: Article
ISSN: 0340-6997
DOI: 10.1007/s00431-010-1189-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Phenotypic classification of male pseudo

Phenotypic classification of male pseudohermaphroditism due to steroid 5α-reductase 2 deficiency

✍ Sinnecker, Gernot H. G.; Hiort, Olaf; Dibbelt, Leif; Albers, Norbert; Dörr, Helm 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 46 KB

Conversion of testosterone (T) to dihydrotestosterone (DHT) in genital tissue is catalysed by the enzyme 5a-reductase 2, which is encoded by the SRD5A2 gene. The potent androgen DHT is required for full masculinization of the external genitalia. Mutations of the SRD5A2 gene inhibit enzyme activity,

New mutations, hotspots, and founder eff

New mutations, hotspots, and founder effects in Brazilian patients with steroid 5α-reductase deficiency type 2

✍ Christine Hackel; Luiz Eduardo Chimello Oliveira; Lucio Fabio Caldas Ferraz; Mar 📂 Article 📅 2005 🏛 Springer 🌐 English ⚖ 212 KB

Molecular analysis of the 5α-steroid red

Molecular analysis of the 5α-steroid reductase type 2 gene in a family with deficiency of the enzyme

✍ Vilchis, F.; Canto, P.; Chávez, B.; Ulloa-Aguirre, A.; Méndez, J. P. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB 👁 1 views

This report describes the identification of a point mutation in the 5␣-reductase type 2 (5␣-SR2) gene from a family in which both sibs (6 and 3 years old) have steroid 5␣-reductase 2 deficiency. The five exons of the gene were individually amplified by the polymerase chain reaction (PCR) and analyse

Sexual dimorphism of growth plate prehyp

Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5-alpha reductase type 1

✍ P. Raz; E. Nasatzky; B.D. Boyan; A. Ornoy; Z. Schwartz 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB

## Abstract Rat costochondral growth plate chondrocytes exhibit sex‐specific and cell maturation dependent responses to testosterone. Only male cells respond to testosterone, although testosterone receptors are present in both male and female cells, suggesting other mechanisms are involved. We exam