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Practical and Enantiospecific Synthesis of LY303870, a Novel NK-1 Antagonist

✍ Scribed by Hipskind, Philip A.; Howbert, J. Jeffry; Cho, Stephen; Cronin, Jason S.; Fort, Stuart L.; Ginah, Francis O.; Hansen, Guy J.; Huff, Bret E.; Lobb, Karen L.

Book ID
124095769
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
464 KB
Volume
60
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES

Practical enantiospecific synthesis of R
Practical enantiospecific synthesis of RPR 111905: A novel non-peptide substance P antagonist
✍ StΓ©phane Mutti; Christophe DaubiΓ©; JoΓ«l Malpart; Xavier Radisson πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 French βš– 193 KB

The synthesis of enantiomerically pure RPR 111905 was achieved in twelve steps with an overall yield of 6.9%. The synthetic strategy was based on a Diels-Alder reaction to generate the bicyclic framework and the asymmetry was introduced by resolution.