PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet

✍ Scribed by Marta Garaulet; Caren E Smith; Teresa Hernández-González; Yu-Chi Lee; Jose M. Ordovás

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 147 KB
• Volume: 55
• Category: Article
• ISSN: 1613-4125
• DOI: 10.1002/mnfr.201100437

✦ Synopsis

Abstract

Scope: The goal of this study was to examine whether the Pro12Ala polymorphism of peroxisome proliferator‐activated receptor γ (__PPAR__γ) is associated with insulin resistance, obesity and weight loss and to analyze potential interactions between fat intake and __PPAR__γ polymorphism in a Spanish overweight/obese population.

Materials and methods: We recruited 1465 subjects enrolled in a behavioural treatment program for obesity based on a Mediterranean diet, which included the following: dietary treatment, physical activity, nutritional education and behavioral techniques. A significant association was found between __PPAR__γ2 Pro12Ala genotype and plasma insulin concentration and homeostasis model assessment insulin resistance. Subjects with the Ala12 genotype had lower insulin levels than those with the Pro12Pro genotype. We detected a gene–diet interaction between the __PPAR__γ Pro12Ala polymorphism and MUFA for BMI and body fat. Furthermore, we detected an interaction between the __PPAR__γ Pro12Ala polymorphism and fat intake for total weight loss (p<0.001). When total fat intake was high, Ala12‐carriers exhibited a significantly lower percentage of total weight loss than major‐allele‐carriers (p=0.037).

Conclusion: Data are consistent with previous results showing a protective role for the Ala12 allele against insulin resistance, and replicate an earlier study that detected an interaction between dietary MUFA and __PPAR__γ2 for BMI. Our detection of a gene–diet interaction between __PPAR__γ Pro12Ala and fat intake for weight loss may explain previous discrepancies among different studies.