PPARΓ agonist inhffiits cell growth of H-ras transformed rat intestinal epithelial cells through the suppression of transcriptional activities of AP-1 and Ets

PPARγ agonists inhibit cell growth and s

PPARγ agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells

✍ Shinji Kitamura; Yoshiji Miyazaki; Shintaro Hiraoka; Yutaka Nagasawa; Miyuki Toy 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 265 KB

Peroxisome proliferator-activated receptor ␥ (PPAR␥) inhibits the growth of several types of cancer cells. However, the mechanisms by which this occurs are poorly understood. The goal of the present study was to investigate the effects of PPAR␥ on mutated ras-induced cell growth, activation of trans