We successfully synthesized a novel peroxisome proliferator-activated receptor (PPAR)d selective agonist, namely, compound 20, with a characteristic benzisoxazole ring. Compound 20 exhibited potent human PPARd transactivation activity and high d selectivity. Further, it stimulated differentiation of
PPAR δ agonists stimulate oligodendrocyte differentiation in tissue culture
✍ Scribed by Inderjeet Saluja; James G. Granneman; Robert P. Skoff
- Book ID
- 102677947
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 812 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0894-1491
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## Abstract Peroxisome proliferator‐activated receptors (PPARs) are key transcription factors in the control of lipid homeostasis and cell differentiation, but little is known about their function in oligodendrocytes, the major lipid‐synthesizing cells in the central nervous system (CNS). Using the
Perturbation of myelinogenesis by monoclonal antibodies against galactolipids is being used to study the role of these lipids in oligodendrocyte differentiation. We report here a marked stimulatory effect on oligodendrocyte differentiation when mixed primary cultures initiated from 19-21 day fetal r