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PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress

✍ Scribed by Lourdes Garcia; Fatima Garcia; Franc Llorens; Mercedes Unzeta; Emilio Itarte; Néstor Gómez

Book ID
117104368
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
278 KB
Volume
523
Category
Article
ISSN
0014-5793

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We have reported that treatment with okadaic acid, a potent protein phosphatase inhibitor, has the ability to enhance the synthesis of the 78-kDa glucose-regulated protein (GRP78). This article reports our investigation of another protein phosphatase inhibitor, calyculin A, demonstrating the signali