Epidermal growth factor (EGF), a mitogen in vitro for hepatocytes, produces in various cell lines changes similar to those observed very rapidly in hepatocytes after partial hepatectomy (PH). These changes include ion movements, membrane hyperpolarization and proto-oncogene expression. A stimulatory
PP067-MON EFFECTS OF INSULIN, GLUCAGON, AND EPIDERMAL GROWTH FACTOR ON LIVER REGENERATION AFTER PARTIAL HEPATECTOMY
β Scribed by Lai, H.-S.; Lai, S.-L.; Wu, S.-C.; Chen, W.-J.
- Book ID
- 123436998
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 53 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0261-5614
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The role of epidermal growth factor on liver regeneration after partial hepatectomy in rats was investigated. After a 70% hepatectomy in rats, the concentration of epidermal growth factor in portal venous blood was unchanged compared with unoperated controls. However, small amounts of epidermal grow
Several growth factors including hepatocyte growth factor (HGF) have been implicated in the regulation of liver regeneration. Recently, we reported that heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) has hepatotrophic effects in vitro. We investigated the role of HB-EGF as
When epidermal growth factor was given to rats after partial hepatectomy, hepatic putrescine content was significantly increased at 4, 6 and 10 hr compared with control rats. Ornithine decarboxylase activity was also increased. Hepatic ornithine decarboxylase messenger RNA content was significantly