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p,p′-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway

✍ Scribed by Yu-Qin Shi; Yu-Ping Wang; Yang Song; Hao-Wen Li; Chang-Jiang Liu; Zhi-Gang Wu; Ke-Di Yang


Book ID
119381821
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
823 KB
Volume
193
Category
Article
ISSN
0378-4274

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Wild-type p53 has a major role in the response and execution of apoptosis after chemotherapy in many cancers. Although high levels of wild-type p53 and hardly any __TP53__ mutations are found in testicular cancer (TC), chemotherapy resistance is still observed in a significant subgroup of TC patient