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Poxvirus Vascular Endothelial Growth Factor (VEGF) Homologs of Orf Virus

✍ Scribed by McFadden G., Moyer R.


Book ID
127399149
Tongue
English
Weight
170 KB
Category
Library

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✦ Synopsis


To date, a viral homolog of vascular endothelial growth factor (VEGF) has been discovered in only one poxvirus, namely orf virus of sheep. Orf virus encodes two such proteins, each of which possesses characteristic cysteine spacing motifs found in cellular VEGF family members. Viral VEGF binds to the members of the same family of cell surface receptors as its cellular counterparts and has proangiogenic activity.


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