## Abstract In caseโcontrol single nucleotide polymorphism (SNP) data, the allele frequency, Hardy Weinberg Disequilibrium, and linkage disequilibrium (LD) contrast tests are three distinct sources of information about genetic association. While all three tests are typically developed in a retrospe
Power of Single- vs. Multi-Marker Tests of Association
โ Scribed by Xuefeng Wang; Nathan J. Morris; Daniel J. Schaid; Robert C. Elston
- Book ID
- 112095656
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 775 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
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## Abstract To detect genetic association with common and complex diseases, many statistical tests have been proposed for candidate gene or genomeโwide association studies with the caseโcontrol design. Due to linkage disequilibrium (LD), multiโmarker association tests can gain power over singleโmar
## Abstract Haplotype analysis is essential to studies of the genetic factors underlying human disease, but requires a large sample size of phaseโknown data. Recently, directly haplotyping individuals was suggested as a means of maximizing the phaseโknown data from a sample. Haplotyping, however, i