## Abstract The familyโbased admixture mapping test (AMT) identifies diseaseโrelated genes using family data from admixed individuals with the disease of interest (cases). The cases' genotypes at a set of markers are used to infer their DNA ancestry as it varies in blocks along the chromosomes. The
Power Comparison of Admixture Mapping and Direct Association Analysis in Genome-Wide Association Studies
โ Scribed by Huaizhen Qin; Xiaofeng Zhu
- Book ID
- 112095632
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 938 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Though multiple interacting loci are likely involved in the etiology of complex diseases, early genomeโwide association studies (GWAS) have depended on the detection of the marginal effects of each locus. Here, we evaluate the power of GWAS in the presence of two linked and potentially
## Abstract Genomeโwide association studies have recently identified many new loci associated with human complex diseases. These newly discovered variants typically have weak effects requiring studies with large numbers of individuals to achieve the statistical power necessary to identify them. Lik
Despite the success of genome-wide association studies, much of the genetic contribution to complex human traits is still unexplained. One potential source of genetic variation that may contribute to this โmissing heritabilityโ is that which differs in magnitude and/or direction between males and fe