Power and Sample Size for Testing Associations of Haplotypes with Complex Traits
โ Scribed by Daniel J. Schaid
- Book ID
- 109117805
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 144 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0003-4800
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract In genetic mapping of complex traits, scored haplotypes are likely to represent only a subset of all causal polymorphisms. At the extreme of this scenario, observed polymorphisms are not themselves functional, and only linked to causal ones via linkage disequilibrium (LD). We will demon
proposed a regression-based TDT method for quantitative traits consisting of regressing the trait on the parental transmission of a marker allele. Zhu and Elston [2000] also developed a TDT method for quantitative traits by defining a linear transformation to condition out founder information. Both