Power and Pitfalls of the Genome-Wide Association Study Approach to Identify Genes for Alzheimer’s Disease
✍ Scribed by Richard Sherva; Lindsay A. Farrer
- Book ID
- 107552233
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 177 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1523-3812
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## Abstract The large number of markers considered in a genome‐wide association study (GWAS) has resulted in a simplification of analyses conducted. Most studies are analyzed one marker at a time using simple tests like the trend test. Methods that account for the special features of genetic associ
As the initial step in a systematic genome survey, 16 simple sequence tandem repeat polymorphisms that span the X chromosome at an average spacing of 10 cM were examined for allelic associations with typical-onset Alzheimer's disease (AD). The efficiency of this survey was substantially enhanced by
As the initial step in a systematic genome survey, 16 simple sequence tandem repeat polymorphisms that span the X chromosome at an average spacing of 10 cM were examined for allelic associations with typicalonset Alzheimer's disease (AD). The efficiency of this survey was substantially enhanced by g