Hypofunction of the N-methyl-D-aspartate receptor (NMDAR) has been implicated in the pathophysiology of schizophrenia. The NMDAR contains a D-serine/glycine site on the NR1 subunit that may be a promising therapeutic target for psychiatric illness. This review outlines the complex regulation of endo
Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site
✍ Scribed by Seong S. Shim; Michael D. Hammonds; Baik S. Kee
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 260 KB
- Volume
- 258
- Category
- Article
- ISSN
- 1433-8491
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We have previously reported that both transferred microglia and microglia‐conditioned medium (MCM) potentiated the __N__‐methyl‐D‐aspatate (NMDA) receptor‐mediated synaptic responses in cortical neurons. To elucidate the mechanism underlying the potentiation of NMDA receptor‐mediated re
## Abstract __N__‐methyl‐D‐aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve cognition, although findings have not been convincing. We used the Cognitive Drug R