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Potentiation of the hCRF-induced release of ACTH in man by an opioid antagonist

✍ Scribed by Ehrenreich, H. ;Kolmar, Ch. ;Müller, O. A. ;Goebel, F. -D.

Book ID
105285864
Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
528 KB
Volume
65
Category
Article
ISSN
1432-1440

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The effects of naltrexone methobromide, a quaternary derivative of the opioid antagonist naltrexone, were investigated on deprivation (24 h)-induced water intake in the unilaterally cannulated rats. Naltrexone methobromide reduced post-deprivational water intake with an ED50 of 7.3 micrograms when t