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Potentiation of RSV rescue from rsv-transformed “poorly” virogenic cell lines by 5-bromodeoxyuridine treatment before fusion with chick embryo fibroblasts

✍ Scribed by L. Donner; H. Sainerová; J. Svoboda; S. Scherneck


Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
406 KB
Volume
13
Category
Article
ISSN
0020-7136

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✦ Synopsis


Abstract

The rescue of RSV from the “poorly” virogenic RSV‐transformed rat lines LW13‐RsK1 and LW13‐RsK4 was achieved only after treatment with 5‐bromodeoxyuridine (BUdR) before fusion with chicken embryo fibroblasts. Treatment of these lines with mitomycin C (MC) before fusion did not result in RSV rescue. Treatment of RSV‐transformed non‐virogenic mouse lines, RVA4 and RVP3, with BUdR or MC before fusion with chick embryo fibroblasts did not lead to the production of RSV.