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Potentiation of okadaic acid-induced ceramide elevation but not apoptosis by inhibition of glucosylceramide synthase in human neuroepithelioma cells

✍ Scribed by Sabrina Di Bartolomeo; Angelo Spinedi

Book ID: 113992607
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 473 KB
Volume: 61
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(01)00569-x

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## Abstract Bisphosphonates (BPs) are widely used in the treatment of osteolytic bone disease associated with multiple myeloma, and have been demonstrated to exert antitumor effects both __in vitro__ and __in vivo__. However, the precise molecular mechanisms involved in the direct antitumor effects