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Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: Role of sigma-1 receptors and IP3 receptors

โœ Scribed by Tamaki Ishima; Tomoko Nishimura; Masaomi Iyo; Kenji Hashimoto


Book ID
116841366
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
392 KB
Volume
32
Category
Article
ISSN
0278-5846

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Mutant PC12 cell clones (PC84 cells) were obtained by transfection with nerve growth factor (NGF) cDNA. These cells secreted active NGF, extended short processes, and proliferated faster than the parental PC12 cells. These features are of great interest because the parental PC12 cells cease prolifer