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Potentiation of large conductance, Ca2+-activated K+ (BK) channels by α5β1 integrin activation in arteriolar smooth muscle

✍ Scribed by Xin Wu; Yan Yang; Peichun Gui; Yoshiro Sohma; Gerald A. Meininger; George E. Davis; Andrew P. Braun; Michael J. Davis


Book ID
110116048
Publisher
Cambridge University Press
Year
2008
Tongue
English
Weight
624 KB
Volume
586
Category
Article
ISSN
0022-3751

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The effect of pinacidil, an opener of ATP-sensitive K + (K ATP ) channels, on large-conductance Ca 2+ -activated K+ (BK Ca ) channels was investigated in cultured endothelial cells of human umbilical veins. In whole cell configuration, pinacidil (30 µM) increased the amplitude of K + outward current