Potentiation of glucocorticoid-induced lysis in refractory and resistant leukemia cells by inhibitors of ADP-ribosylation
โ Scribed by Lou Smets; Ebtisam Abdel Ghaffar Metwally; Edward Knol; Michael Martens
- Book ID
- 113238943
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 602 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0145-2126
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We have studied the role of ADP-ribosylation of chromosomal proteins in the regulation of myeloid cell maturation using the HL-60 cell line as a model. Nuclei isolated from this human promyelocytic leukemia cell line contained (ADP-ribose)n synthetase activity, whereas little or no enzymatic activit
Glucocorticoids increase expression of specific genes by a mechanism involving binding to and "activation" of a specific receptor protein. Other steroids, such as RU 486, bind to the glucocorticoid receptor but the resultant steroidreceptor complex is unable to activate glucocorticoid sensitive gene