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Potentiation of CYP1A1 Gene Expression in MCF-7 Human Breast Cancer Cells Cotreated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and 12-O-Tetradecanoylphorbol-13-Acetate

โœ Scribed by M. Moore; T.R. Narasimhan; M.A. Steinberg; X. Wang; S. Safe


Book ID
115564628
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
602 KB
Volume
305
Category
Article
ISSN
0003-9861

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12-O-tetradecanoylphorbol-13-acetate upr
โœ Barbara C. Spink; Michael J. Fasco; John F. Gierthy; David C. Spink ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 117 KB

Elevated expression of cytochrome P450 1B1 (CYP1B1) and estradiol 4-hydroxylation have been reported to be biomarkers of tumorigenesis in humans. The aromatic hydrocarbon receptor (AhR) regulates expression of human cytochrome P450 1A1 (CYP1A1) and CYP1B1, 17โค-estradiol (E 2 ) 2-and 4-hydroxylases,