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Potentiation of antitumor immunity by antibody-directed enzyme prodrug therapy

โœ Scribed by Bing-Mae Chen; Tian-Lu Cheng; Shey-Cherng Tzou; Steve R. Roffler


Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
234 KB
Volume
94
Category
Article
ISSN
0020-7136

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Novel prodrugs of the cytotoxic antibiotic CC-1065 for an antibody-directed enzyme prodrug therapy (ADEPT) were prepared that show an excellent selectivity with a high toxicity of the corresponding drug. In particular, the seco-CBI analogue of CC-1065, 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]