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Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor

✍ Scribed by Jackson, Michael W; Spencer, Nicolas J; Reed, Joanne H; Smith, Anthony J F; Gordon, Tom P


Book ID
109885297
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
434 KB
Volume
89
Category
Article
ISSN
0023-6837

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The pharmacokinetics of ambenonium, a reversible cholinesterase inhibitor, in rats was investigated following intravenous administration of the drug. Mean residence time and steady state volume of distribution were 23-36 min and 0.2M.311 kg-I, respectively, and were dose independent at the dose of 0