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Potentiation of 1,3-BIS(2-chloroethyl)-1-nitrosourea (BCNU)-induced cytotoxicity in 9L cells by pretreatment with 6-thioguanine

โœ Scribed by William J. Bodell; William F. Morgan; Jytte Rasmussen; Mary E. Williams; Dennis F. Deen


Book ID
115778123
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
653 KB
Volume
34
Category
Article
ISSN
0006-2952

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Pretreatment of 9L cells with either a-difluoromethylornithine (DFMO), which depletes intracellular levels of polyamines, or 6-thioguanine (6TG). which substitutes for guanine in DNA, potentiates the cytotoxic effects of 1,3-bis (2-chloroethy1)-I -nitrosourea (BCNU). We examined the effects of these