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Potentiation of 1,25-dihydroxyvitamin D3-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone

✍ Scribed by Seung H Kim; So N Kang; Hyeoung J Kim; Tae S Kim

Book ID
113993231
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
416 KB
Volume
64
Category
Article
ISSN
0006-2952

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## Abstract Recent studies revealed that the MEK/ERK module of the mitogen‐activated protein kinase (MAPK) signaling cascades is up‐regulated in the early stages of 1α,25‐dihydroxyvitamin D~3~ (1,25D~3~)‐induced monocytic differentiation of human leukemia cells HL60. In the present study, we invest