𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Potentiating interactions between morphogenetic protein and neurotrophic factors in developing neurons

✍ Scribed by Henrik Bengtsson; Stine Söderström; Annika Kylberg; Marc F. Charette; Ted Ebendal

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
425 KB
Volume
53
Category
Article
ISSN
0360-4012

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✦ Synopsis

mRNA for bone morphogenetic protein receptor type II (BMPR-II) was mapped to different neurons in peripheral ganglia and spinal cord of the chicken embryo. The expression of this serine/threonine kinase receptor partially overlaps with that of tyrosine kinase receptors Trk and Ret. Biological activities of osteogenic protein-1 (OP-1), a documented ligand for BMPR-II, were tested in explanted embryonic chicken ganglia and dissociated ganglionic neurons. OP-1 had only a limited stimulatory effect on neuronal survival. However, OP-1 combined with either neurotrophin-3 (NT-3, a relative of nerve growth factor) or glial cell line-derived neurotrophic factor (GDNF) potentiated neuronal survival three- to fourfold. We also show that OP-1 strongly potentiates nerve fiber outgrowth from ganglia stimulated with NT-3 or GDNF. Signaling by BMPR-II in neurons may potentiate the tyrosine kinase pathway activated by NT-3 and GDNF. The data suggest that morphogenetic proteins may modulate neurotrophic activities during neuronal development and plasticity.

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