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Potentiating action of salts of bivalent and trivalent metals on the analgesic effect of morphine

✍ Scribed by O. N. Chichenkov; N. V. Porodenko; S. V. Zaitsev

Book ID
104966945
Publisher
Springer US
Year
1985
Tongue
English
Weight
358 KB
Volume
100
Category
Article
ISSN
0007-4888

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Effect of midbrain raphe lesion on the a
Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats
✍ R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli πŸ“‚ Article πŸ“… 1973 πŸ› Springer 🌐 English βš– 267 KB

The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine