✦ LIBER ✦

Potentiating Action of 5-Fluorouracil When Used in Combination with Platinum Compounds and Cyclophosphamide in Treatment of Advanced L1210 Leukemia

✍ Scribed by Glen R. Gale; Loretta M. Atkins; Paul Schwartz; Sandra J. Meischen

Publisher: Elsevier Science
Year: 1978
Weight: 309 KB
Volume: 8
Category: Article
ISSN: 0006-3061
DOI: 10.1016/s0006-3061(00)80279-3

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✦ Synopsis

Nine new organoplatinum (PO compounds, cyclophosphamide (CY), and 5-fluorouracil (FU) were used singly and in combination in treatment of advanced Ll210 leukemia in C57BL/6 X DBA/2 hybrid mice. In each experiment the Pt + CY dual combination was minimally supra-additive at the doses chosen. However, eight of the nine Pt + CY + FU combination regimens enhanced markedly the increased life span of treated mice as compared with the corresponding dual Pt + CY combination. Collectively, the cure rate (>60day survival) was less than 6% with the various Pt + CY combinations, and was increased to over 63% upon inclusion of FU in the regimens.

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