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Potential Role for Therapies Targeting DKK1, LRP5, and Serotonin in the Treatment of Osteoporosis

✍ Scribed by Wei Zhang; Matthew T. Drake

Book ID
113091849
Publisher
Current Science Inc.
Year
2011
Tongue
English
Weight
331 KB
Volume
10
Category
Article
ISSN
1544-1873

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## Abstract Dkk1 is a secreted antagonist of the LRP5‐mediated Wnt signaling pathway that plays a pivotal role in bone biology. Because there are no well‐documented LRP5‐based assays of Dkk1 binding, we developed a cell‐based assay of Dkk1/LRP5 binding using radioactive ^125^I‐Dkk1. In contrast to