Potential photosensitizers for photodynamic therapy: IV. Photophysical and photochemical properties of azaporphyrin and azachlorin derivatives

✍ Scribed by K. Schiwon; H.-D. Brauer; B. Gerlach; C.M. Müller; F.-P. Montforts

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 581 KB
• Volume: 23
• Category: Article
• ISSN: 1011-1344
• DOI: 10.1016/1011-1344(94)07000-8

✦ Synopsis

The photophysical and photochemical properties of a 5-azaprotoporphyrin derivative ([5]AZPP), a zinc-15-azaporphyrin derivative (Zn-[15]AZIDP) and an E-Z isomeric mixture of a 5-azachlorin derivative ([5]AZCH) were studied in various solvents. The quantum yields of fluorescence phi F0, S1-T1 intersystem crossing phi T0 and singlet oxygen (1 delta g) formation phi delta were measured and the Stern-Volmer constants for the quenching of the S1 states by oxygen and the rate constants of quenching of O2(1 delta g) by the different azaporphyrinoid compounds were obtained. The fluorescence quantum yield (phi F0 = 0.23), the strong absorption in the red (lambda max = 674 nm, epsilon max = 66,000 M-1 cm-1) and the high value of the quantum yield for singlet oxygen (1 delta g) formation (phi delta = 0.65) observed for [5]AZCH recommend azachlorin derivatives as potential markers and photosensitizers for tumour therapy.