Disseminated intravascular coagulation (DIC) is a frequent occurrence in acute promyelocytic leukemia (APL), especially after onset of chemotherapy. We have used a human promyelocytic leukemic established cell line (HL-60) and various other human leukemic cells to investigate the effect of cytotoxic
✦ LIBER ✦
Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro
✍ Scribed by Murray, Benjamin S.; Crot, Stéphanie; Siankevich, Sviatlana; Dyson, Paul J.
- Book ID
- 127256913
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 689 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0020-1669
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## Abstract Single‐cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vit