Subcritical fluid chromatography (SubFC) using a carbon dioxidemethanol mobile phase is used for the chiral resolution of IIb/IIIa receptor antagonist enantiomers. The chiral resolution of three analogs, each containing two chiral centers, is optimized using various mobile phase additives. The effec
β¦ LIBER β¦
Potential of chiral anion-exchangers operated in various subcritical fluid chromatography modes for resolution of chiral acids
β Scribed by Reinhard Pell; Wolfgang Lindner
- Book ID
- 116362687
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 716 KB
- Volume
- 1245
- Category
- Article
- ISSN
- 1873-3778
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The enantiodiscriminating potential of the weak anion exchange-type quinine-based chiral stationary phases (CSPs) for direct enantiomer separation of racemic 2-methoxy-2-(1-naphthyl)propionic acid (selectand, SA) was studied. The influence of structure variations of the selector (SO) in the carbamat