Potential H1-Antihistaminic Drugs: Synthesis of 4-[(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)alkoxycarbonyl]-1-(diphenylmethyl)piperazines by Selective Monoalkoxycarbonylation of α,ω-Dichloroalkanes by Phase-Transfer Catalysis

✍ Scribed by Gómez-Parra, Vicente ;Jiménez, Mercedes ;Sánchez, Félix ;Torres, TomáS

• Book ID: 102900320
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 653 KB
• Volume: 1989
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.198919890195

✦ Synopsis

Compounds incorporating the (piperazinylalky1)benzimidazolone group show interesting biological activity. Oxatomide (1) is a clinically useful anti-Hi-histaminic agent with probable mast cell stabilization activity. 8 \ RZ 1 2

Experiment a1

Melting points are uncorrected. -'H-and '3C-NMR spectra were registered with a Bruker WP 200 SY instrument (200 MHz), mass spectra with a Hewlett-Packard 5985, and infrared spectra with a Perkin-Elmer 257. -Silica gel, Merck, 70-230 mesh, 230-400 mesh, and DC-Alufolien 60, were used for conventional, flash, and analytical thin-layer chromatography, respectively.