Potential glucose sensor for perioperative blood glucose control in diabetes mellitus

✍ Scribed by Katherine R. Greenough; Andrew W. Skillen; Calum J. McNeil

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 506 KB
• Volume: 9
• Category: Article
• ISSN: 0956-5663
• DOI: 10.1016/0956-5663(94)80011-1

✦ Synopsis

A glucose sensor intended for future use in diabetic patients undergoing major surgery is described. It involves glucose oxidase immobilised at a platinised activated carbon electrode (PACE). The sensor gave a nonoxygen dependent amperometric response in whole undiluted blood and did not require the use of electron mediators. In vitro studies in protein containing buffer using a flow cell indicated current densities of approximately 160 nA mrne2 mM-' and a linear response over the range O-20 mM. The operational stability of the sensor was at least 49 h in continuous use. In addition the sensor had a 90-99% response time of 1 min when used at a flow rate of 3 ml min-' and showed a temperature dependence of 2.4% C-l. The results reported suggest significant advantages of this approach, for future use as a perioperative intra-vascular sensor for diabetic subjects, over previously reported glucose sensors.